Screening for NewMetabolites from Marine Microorganisms

This article gives an overview of current analysis techniques for the screening

and the activity analysis of metabolites from marine (micro)organisms. The sequencing

of marine genomes and the techniques of functional genomics (including transcriptome,

proteome, and metabolome analyses) open up new possibilities for the screening of new

metabolites of biotechnological interest. Although the sequencing of microbial marine

genomes has been somewhat limited to date, selected genome sequences of marine bacteria

and algae have already been published. This report summarizes the application

of the techniques of functional genomics, such as transcriptome analysis in combination

with high-resolution two-dimensional polyacrylamide gelelectrophoresis and mass

spectrometry, for the screening for bioactive compounds of marine microorganisms.

Furthermore, the target analysis of antimicrobial compounds by proteome or transcriptome

analysis of bacterial model systems is described. Recent high-throughput screening

techniques are explained. Finally, new approaches for the screening of metabolites from

marine microorganisms are discussed.

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